Figure 1.

Gut microbiota and muscle aging. Age-related lifestyles, including decreased physical function, nutrition intake and living status, would induced the changes of gut microbiota. The increased Bifidobacteria, Christensenellaceae, and Akkermansia were identified as aging-core-microbiota. The substantial microbiome change in aging may affect changes in gut physiology such as reduced gut motility, reduced mucus, barrier dysfunction, and dysbiosis, which can further mediate the translocation of bacterial toxins and muscle aging. “+” means increased, “-” means decreased.