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. 2019 Feb 1;10(1):174–189. doi: 10.14336/AD.2017.1213

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Copyright: © 2019 Cakouros et al.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 3. — Chromatin Structure of Stemness and differentiation genes in Aged HSC/MSC. Histone and DNA modification marks in aged HSC and MSC consist of DNA methylation, H3K9me3 and H3K27me3 being more abundant along lineage/differentiation promoters therefore inhibiting transcription and differentiation. This is more apparent on lymphoid genes in HSC therefore skewing differentiation towards the myeloid lineage. Stemness genes contain an abundance of active marks such as H3K4me1, H3K4me3 and H3K27Ac leading to an open chromatin conformation and keeping the adult stem cells in an immature state.