Table 2.
Effects of aging and end stage renal disease in the absolute numbers (cells/mm3) of lymphocyte subpopulations among healthy adults, healthy elderly, adult ESRD patients and elderly ESRD patients.
| HAd (n=14) | HEld (n=15) | EnAd (n=17) | EnEld (n=27) | |
|---|---|---|---|---|
| Total Lymp | 2515 (2033-2688) | 2060 (1500-2200)a | 2100 (1605-2395)b | 1370 (1000-1600)c,e,f |
| T | 1737 (1446-1933) | 1172 (934.3-1360)a | 1238 (847.3-1599)b | 718 (483.7-992.8)c,e,f |
| TCD4 | 997.2 (813.1-1205) | 670 (597.2-999.3)a | 724.9 (508-951)b | 470.2 (274.5-631.2)c,e,f |
| TCD8 | 584 (403.2-761.8) | 322.5 (210.1-510.6)a | 380.5 (281.1-501.3)b | 213 (147.9-359.8)c,f |
| B | 243 (175.2-313.1) | 229 (127.7-321.4) | 165.1 (115.5-227.9)b | 82 (56.5-137.2)c,e,f |
| T naive | 228.5 (111.1-337.4) | 155.3 (86.2-246.9) | 106.1 (45.4-234.2)b | 89 (25.1-138)c,e |
| TCM | 66.9 (44.4-86.8) | 68.4 (39.6-85.6) | 59.1 (16.5-75.6) | 35 (19.6-62)c,e |
| TEM | 262.5 (156.1-421.4) | 201.2 (145.8-254.2) | 234.8 (162.3-338.8) | 164.4 (88.6-230.5)c,f |
| TEMRA | 354.1 (263.8-470.3) | 190.5 (104.3-315)a | 293.4 (107.4-323.3)b | 120 (64.6-179.2)c,e,f |
| TREG | 24 (10.6-29.2) | 24.1 (15.4-34.5) | 12.9 (3 -16.5)d | 8.9 (4.8-18.1)c,e |
| B naive | 106.5 (71.6-132.5) | 87.4 (34.7-116.2) | 49.7 (33-75.9)b | 23.4 (11.2-47.7)c,e,f |
| BM | 69.1 (42.6-85.1) | 43.9 (23.9-70.8) | 45.4 (26.5-52.5)b | 26.4 (7-32)c,e,f |
| BREG | 15.5 (8.9-22.3) | 18.5 (9.8-30.5) | 12.3 (7.1-17.3) | 7.5 (2.4-15.7)c,e |
HAd - healthy adults; HEld - healthy elderly; EnAd - end stage renal disease adult patients; EnEld - end stage renal disease elderly patients; Lymp - lymphocyte; T - T lymphocyte; TCD4 - T helper; TCD8 - T cytotoxic; B - B lymphocyte; TCM - T central memory; TEM - T effector memory; TEMRA - T effector memory with RA reexpression; TREG - regulatory T cells; BM - B memory; BREG - regulatory B cells. Significant difference between:
a
HAd and HEld;
b
HAd and EnAd;
c
HAd and EnEld;
d
HEld and EnAd;
e
HEld and EnEld;
f
EnAd and EnEld