a, Type I crystal lattice of MhsT (4US4), bacterial sodium driven symporter (NSS family). b, Type II crystal lattice observed in MdfA (4ZP0), a DHA1 multi-drug efflux transporter. c, Schematic representation of Pn3m lipidic cubic phase (LCP) shown with induction of crystal nucleation at the centre (figure used from http://cherezov.usc.edu/resources.htm). d, Pictorial representation of the bicelle crystallisation method.