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Pepducins as inhibitors of GPCR-Gq signaling. Agonist-promoted calcium mobilization was monitored by Fura-2 AM fluorescence in agonist-stimulated HEK293 (PAR1-AP, ATP, Carbachol) and human ASM cells (Bradykinin, Histamine) pretreated for 1 min with indicated concentrations of P4pal-10. Data from Carr et al. Mol Pharmacol 2016; values are mean ± SD, n = 3.
