Skip to main content
. 2019 Jan 24;14(1):e0210914. doi: 10.1371/journal.pone.0210914

Fig 4. Tacrolimus levels in forelimb VCA skin tissue in high dose group.

Fig 4

Animals receiving hydrogels containing 91 mg (total dose) of TAC demonstrated a burst release of TAC (ranging between 500 and 1500 ng/gm) in forelimb skin tissue at POD 1 that coincided with macrophage activation secondary to inflammatory events from surgical trauma and ischemia- reperfusion injury. A secondary spike of TAC release was observed at around POD 7 in all animals that possibly coincides with onset of AR events in the VCA. Mean TAC levels coinciding with macrophage-mediated graft immune events are shown. Standard deviations (SD) of TAC levels in triplicate tissue samples are shown.