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. 2019 Jan 24;14(1):e0211071. doi: 10.1371/journal.pone.0211071

Fig 5. The RARα-synthetic agonist AM80 increases levels of F4/80 in HFD-fed mice.

Fig 5

Representative images depicting hepatic Kupffer cells stained with the F4/80 marker in green and nuclei in blue (Hoechst labeling) in chow-, HFD-, HFD+AM80-, and HFD+AC261066-treated mice assessed by immunofluorescence in frozen liver tissues. Red arrows indicate representative areas positive for F4/80. The plots are represented as mean ± standard deviation (SD); Mice per group = 4; Image fields measured per mouse > 4; Statistical significance is assessed by one way ANOVA (black stars), p < 0.05 = *; p < 0.01 = **; p < 0.0001 = ****. Magnification = 200X. Scale bar = 100 μm.