Table 2. NTHI and SP-mediated reductions in bacterial recognition receptor expression on MDMs from subjects with COPD and smokers.

Receptor	COPD Ex-Smoker	COPD Smoker	Healthy Smoker	COPD Ex-Smoker	COPD Smoker	Healthy Smoker
SRA-I	p = 0.008	p<0.0001	p<0.0001	p = 0.008	p = 0.01	p<0.0001
MARCO	p = 0.05	p = 0.61	p = 0.007	p = 0.03	p = 0.44	p = 0.07
CD11b	p = 0.002	p = 0.002	p = 0.004	p = 0.44	p = 0.34	p = 0.99
CD35	p = 0.02	p = 0.25	p<0.0001	p = 0.13	p = 0.16	p = 0.04
CD206	p = 0.008	p = 0.21	p = 0.0001	p = 0.25	p = 0.73	p = 0.96
CD1d	p = 0.06	p = 0.31	p = 0.004	p = 0.002	p = 0.01	p<0.0001
TLR2	p = 0.52	p = 0.56	p = 0.03	p = 0.002	p = 0.002	p = 0.06
TLR4	p = 0.13	p = 0.83	p = 0.001	p = 0.003	p = 0.03	p = 0.001
CD93	p = 0.10	p = 0.08	p = 0.002	p = 0.03	p = 0.72	p = 0.25
CD14	p = 0.11	p = 0.08	p<0.0001	p = 0.85	p = 0.52	p = 0.58
CD16	p = 0.19	p = 0.73	p = 0.29	p = 0.11	p = 0.09	p = 0.10

Analysis by paired T-test of log-transformed receptor MFI (mean fluorescence intensity) representative of cell surface receptor density after NTHI or SP exposure, as compared to baseline receptor expression with representative p-values listed. Light grey shading for SR-AI and MARCO denote receptors reduced by both NTHI and SP. Italicized p-values did not reach statistical significance. Benjamini-Hochberg correction for multiple comparisons (false discovery rate) was done, accepting a threshold of 0.10 given the exploratory nature of the study, which was consistent with uncorrected p-values meeting the pre-specified significance level of ≤0.05.