Table 2. The list of TG derivatives with their experimental IC50 against DENV -2 NS2B/NS3pro.
Ligands | R1 | R2 | R3 | IC50 (μM) |
---|---|---|---|---|
1 | (4-nitrophenyl)methanimine | H | H | 1995 |
2 | 4-(iminomethyl)benzoic acid | H | H | 1367 |
3 | 4-(iminomethyl)-2-methoxy-6-nitrophenol | H | H | 28 |
4 | 3-methoxybenzenesulfinic acid | H | H | 68 |
5 | 4-methoxybenzenesulfinic acid | H | H | 55 |
6 | 3-methylbenzenesulfinic acid | 3-methylbenzenesulfinic acid | H | 63 |
7 | acetyl | H | H | 151 |
8 | butanoyl | H | H | 57 |
9 | isobutanoyl | H | H | 3893 |
10 | pentanoyl | H | H | 1037 |
11 | 3-methylbutanoyl | H | H | 80 |
12 | hexanoyl | H | H | 168 |
13 | palmitoyl | H | H | 132 |
14 | benzoyl | H | H | 370 |
15 | acetyl | H | cyclopentyl | 556 |
D0713 | H | 2-methylpyridine | cyclopentyl | 62 |
TG | H | H | H | 753 |
Panduratin A | - | - | - | 56 |