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. 2019 Jan 24;14(1):e0210869. doi: 10.1371/journal.pone.0210869

Table 3. The structures of six newly designed compounds and their activity against DENV-2 NS2B/NS3pro.

Ligands R1 R2 R3 IC50 (μM)
16 propanoyl propanoyl H 97
17 isopropanoyl isopropanoyl H 80
18 pentanoyl pentanoyl H 0.38
19 pentanoyl benzyl H 54
20 H 2-methylnaphtyl isopropyl 258
21 pentanoyl benzyl benzyl 16