Table 2-.
Urinary PAH and lung function (%predicted) and FeNO in children, by asthma status
| No current asthma (n=2,170) |
Current asthma (n=289) |
|
|---|---|---|
| Outcomes | β (95% confidence interval) | |
| ΣmolPAHsa | ||
| %predicted FEV1 | 0.94 (−0.31, 2.18) | −3.80 (−6.68, −0.88)† |
| %predicted FVC | 1.19 (−0.01, 2.36) | −2.13 (−5.12, 0.87) |
| %predicted FEV1/FVC | −0.10 (−0.84, 0.64) | −2.43 (−5.34, 0.49) |
| FeNO (ppb) | −0.57 (−2.01, 0.87) | −0.71 (−5.23, 3.80) |
| Σmol2-PAHsb | ||
| %predicted FEV1 | 0.67 (−0.50, 1.84) | −3.47 (−6.07, −0.88)† |
| %predicted FVC | 0.90 (−0.19, 2.00) | −2.20 (−4.79, 0.39) |
| %predicted FEV1/FVC | −0.09 (−0.80, 0.62) | −1.14 (−3.23, 0.96) |
| FeNO (ppb) | −0.44 (−1.81, 0.93) | −0.15 (−4.10, 3.79) |
| Σmol3,4-PAHsc | ||
| %predicted FEV1 | 0.59 (−1.33, 2.51) | −3.83 (−8.74, 1.09) |
| %predicted FVC | 0.42 (−1.37, 2.21) | −2.93 (−7.28, 1.42) |
| %predicted FEV1/FVC | 0.30 (−0.81, 1.42) | −1.27 (−4.33, 1.79) |
| FeNO (ppb) | −1.87 (−3.73, 0.01) | 2.12 (−3.98, 8.21) |
All models adjusting for health insurance coverage, BMI z-score, use of oral or inhaled steroids in the past 2 days, serum cotinine, and urinary creatinine level. Models for FeNO in additionally adjusting for age, gender, and race/ethnicity.
a
ΣmolPAHs = sum of all urinary PAH metabolites
b
Σmol2-PAHs = sum of urinary PAHs with 2 benzene rings
c
Σmol3,4-PAHs = sum of urinary PAHs with 3 or 4 benzene rings
†
P<0.05