Figure 1.

Amino Acid Profile of Feedback-Dysregulated E. coli Mutants

(A) Seven amino acid pathways were dysregulated by genomic point mutations in the indicated genes. See also Table S1. Negative allosteric feedbacks of amino acids on enzymes in the biosynthetic pathways are shown as dotted lines. Negative transcriptional feedbacks of amino acids are shown as dashed lines. Boxes indicate enzymes in the biosynthesis pathways.

(B) Relative concentrations of intracellular amino acids in wild-type E. coli and the seven dysregulated mutants. Bar plots show absolute concentrations of the amino acid in the dysregulated pathways. See also Figure S2. Data are represented as mean, and error bars are ± SD (n = 3).