The top panel shows representative STE images along with the heart rate (HR), ejection fraction (EF), fractional shortening (FS), and global longitudinal strain (GLS) of WT (left) and cMyBPC−/− (right) mouse myocardium. The regional time-to-peak strain (left) and time-to-peak strain rate (right) are shown below WT and cMyBPC−/− STE images. Notably, cMyBPC−/− STE shows reduced GLS, shortened time-to-peak strain, and shortened time-to-peak strain rate.