Table 3.
Pharmacokinetic parameters of dovitinib, gemcitabine, and capecitabine administered concurrently. Gemcitabine AUC 0–7.5 hours, capecitabine AUC 0–8 hours, dovitinib AUC 0–24 hours.
| Day | Drug | T1/2 (hr) | Cmax (ng/mL) | AUC (hr·ng/mL) | |
|---|---|---|---|---|---|
| Day 1 | Gemcitabine | N | 7 | 7 | 7 |
| Min | 0.7 | 5640 | 6370 | ||
| Median | 4.55 | 14000 | 9237 | ||
| Max | 11.89 | 25000 | 12222 | ||
| Capecitabine | N | 5 | 7 | 7 | |
| Min | 0.68 | 98.8 | 488 | ||
| Median | 1.05 | 5150 | 4229 | ||
| Max | 4.07 | 30300 | 14439 | ||
| Dovitinib | N | 1 | 9 | 9 | |
| Min | 15.34 | 99.4 | 1529 | ||
| Median | 15.34 | 181 | 3419 | ||
| Max | 15.34 | 279 | 5394 | ||
| Day 19 | Dovitinib | N | 5 | 5 | 5 |
| Min | 9.38 | 80.1 | 1198 | ||
| Median | 13.17 | 221 | 3854 | ||
| Max | 19.84 | 313 | 4261 |