Skip to main content
. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2018 Jul 25;1865(11 Pt B):1795–1804. doi: 10.1016/j.bbamcr.2018.07.020

Figure 1. B-cell receptor (BCR) signaling pathways important to the pathophysiology and treatment options for chronic lymphocytic leukemia (CLL).

Figure 1.

A critical step in BCR signaling is Bruton’s tyrosine kinase (BTK) which feeds forward into IP3 receptor-mediated Ca2+ release from the ER (left side of figure) and through the Ras-Raf-Mek-Erk pathway (right side of figure). The Bcl-2 protein is located on both the ER and mitochondria where it regulates Ca2+ signals important in generating a variety of light and death decisions.