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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2018 Jul 25;1865(11 Pt B):1795–1804. doi: 10.1016/j.bbamcr.2018.07.020

Figure 3. Bcl-2-IP3R interacting sites and derivation of BIRD-2.

Figure 3.

The BH4 domain of Bcl-2 binds to IP3R domain 3 (red) and a region near domain 6 (green). BIRD-2 is a 20 amino acid synthetic peptide based on a coiled coil region in IP3R domain 3, with a DD/AA mutation introduced to block a protease cleavage site. BIRD-2 binds to the BH4 domain of Bcl-2 and functions as a decoy peptide, inhibiting Bcl-2-IP3R interaction and inducing cell death in Bcl-2-positive malignancies.