Fig. 3.

Fluorescence light microscopy of bone formation around, and within sheep distal femur defects. Panels are presented in order of decreasing stiffness, left to right, and show in cross-section the entire scaffold and associated bone (top panels, after multipanel stitching) and a higher magnification image (bottom panels) as indicated (square). The top panels' scale bars are 2 mm and the bottom panels' scale bars are 150 μm. Short orange line markings in the titanium control sample (bottom panel) indicate the amount of nascent bone deposited during the last 14 days of the experiment. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)