Figure 1.

Process to islet transplantation and factors that contribute to islet loss. Procurement of pancreas from the deceased donor and preservation, islet isolation; pancreatic islets are then transplanted into the portal vein. Islets are lost during these processes due to the influence of many factors. Attempts to avoid loss as a result of these factors are important for improving islet transplantation outcome. BMI, body mass index; HbA1c, hemoglobin A1c; HMGB1, high‐mobility group box 1; IBMIR, instant blood‐mediated inflammatory reaction