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. 2019 Jan 18;9:1538. doi: 10.3389/fphar.2018.01538

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Copyright © 2019 Pan, Shan, Wu, Liu, Lin, Xia, Wang, Zhou and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Micro-CT scanning analysis of bone loss for the effect of PPD on the murine calvarial osteolysis model. (A) Chemical structure of PPD. Molecular formula of C30H52O3 (≥ 97% purity) with an average molecular weight of 460.73. (B) Representative images of reconstructed 3D calvarias from each group. Graphic depiction of (C) bone mineral density (BMD, mg/cc), (D) bone volume/total volume (BV/TV, %), (E) number of pores and (F) total porosity within the ROI of each sample were measured. Significant differences between the groups were determined by ANOVA and Dunnett’s t-test. ^∗P < 0.05 and ^∗∗P < 0.01 compared with the vehicle group. Data are expressed as the means ± SD.