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. 2019 Jan 24;9:548. doi: 10.1038/s41598-018-36985-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Down-regulation of PVT1 inhibited the invasion and migration ability of GC cells. (A,B) The results of CCK8 assay showed that knock down of PVT1 had no obvious effect on cell proliferation in BGC823 and AGS cells (P > 0.05). (C,D) Cell migration assays showed that interference with the expression of PVT1 suppressed the cell migration ability of BGC823 and AGS cells, *P < 0.05. (E,F) Matrigel invasion assays showed that interference with the expression of PVT1 suppressed the cell invasion ability of BGC823 and AGS cells. *P < 0.05.