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. 2019 Jan 24;9:438. doi: 10.1038/s41598-018-36944-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Stage- and species-specific activity of Leish-Box compounds. (A,B) Biparametric dot plots showing the survival of L. donovani parasites (A) and L. amazonensis parasites (B) after three days of treatment at 10 µM for intracellular amastigotes and 4 µM for cultured promastigotes. Results are expressed as percentages of parasite viability compared to DMSO control. Only compounds that were not toxic for BMDMs are represented. Inactive compounds, grey; active only on promastigotes, pink; active only on amastigotes, orange; active on both stages, blue, the color coding correspond to the activity on L. donovani. AmB activity is represented by the white star (panel A), and compounds showing toxicity on L. amazonensis infected macrophages are represented as colored stars (panel B). (C) Biparametric dot plot showing the survival of L. donovani and L. amazonensis amastigotes after three days of treatment at 10 µM. Results are expressed as percentages of parasite viability compared to DMSO control. Only compounds that were not toxic for L. donovani are represented. Compounds with activity on both species are indicated in red. Stars indicate compounds that were specifically toxic on L. amazonensis infected macrophages.