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. 2019 Jan 24;9:636. doi: 10.1038/s41598-018-37213-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Quantitative analysis of RAF dimer induction by RAF inhibitors using split luciferase probes. 293T cells were transiently co-transfected with a pair of RAF split luciferase probe plasmids (Table 1), stimulated with the indicated concentrations of RAF inhibitors for 2 hours, and luciferase activities were measured. Results are presented as fold increases compared with the luciferase activity of vehicle (0.1% DMSO)-treated cells (means ± SD, n = 3). n.s., not significant; otherwise P < 0.05 (one-way ANOVA). Statistical data are provided in Supplementary Table S3.