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. 2019 Jan 24;9:710. doi: 10.1038/s41598-018-35979-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hypoculoside has antifungal activity. (A) Workflow used in the purification and analysis of hypoculoside from Acremonium sp. F2434. (B) Structure of hypoculoside (8) and its aglycone derivative hypoculine (9). (C) Logarithmically growing Candida albicans cells were exposed to hypoculoside and amphotericin B at various concentrations in triplicates in a 96-well microplate. Growth of the cells was quantified by recording the absorbance at 600 nm after 24 hours. Growth (normalized with respect to DMSO-treated cells) is plotted against log of concentration of the compound. A picture of the microplate after 24 hours of incubation at 30 °C is shown in Supplementary Fig. S2A. (D) Effect of hypoculoside on the growth of Saccharomyces cerevisiae cells grown in YPD medium was analyzed in the similar way as for Candida albicans described above in C.