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. 2019 Jan 24;9:716. doi: 10.1038/s41598-018-36902-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of LOC105375913 overexpression on tubulointerstitial fibrosis in mice. (a) PCR analysis of LOC105375913 in tubulointerstitial tissues of mice treated with control plasmid or LOC105375913-expressing plasmid; (b) ISH analysis of LOC105375913 in tubulointerstitial tissues of mice (n = 6); (c) Masson staining of renal sections in mice (n = 6); (d) Level of serum creatinine in mice (n = 6); (e) Level of pri-miR-27b and miR-27b in tubulointerstitial tissues of mice (n = 6); (f) RNA pull-down and RT-PCR analysis of the binding between LOC105375913 and miR-27b in tubulointerstitial tissues of mice (n = 6); (g) Western blot analysis of snail in tubulointerstitial tissues of mice (n = 6); (h) RT-PCR analysis of FN and Col I in tubulointerstitial tissues of mice (n = 6); (i) Western blot analysis of FN and Col I in tubulointerstitial tissues of mice (n = 6). For statistical analysis, a two-tailed Student’s t-test was used for (d,e and h), and one-way ANOVA with Tukey’s post hoc test was used for (f). *P < 0.05 compared with mice treated with control plasmid. Bar = 20 μm.