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. 2019 Jan 24;9:472. doi: 10.1038/s41598-018-36778-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vitro osteogenic ability of hSF-MSCs on PEKK scaffolds. (a) Standardized ALP activity of hSF-MSCs cultured on PEKK and TCP, with or without osteogenic induction for 1, 4, 7, 14, and 21 days. (b) OPN, OCN, COLIA1, ALP, and RUNX2 gene expression of hSF-MSCs cultured for 21 days on PEKK or TCP, with or without osteogenic induction. Note: PEKK + SF: PEKK seeded with hSF-MSCs; PEKK + OS: PEKK seeded with osteogenically-induced hSF-MSCs; TCP + OS: TCP seeded with osteogenically-induced hSF-MSCs; TCP + SF: TCP seeded with hSF-MSCs. Data are presented as mean ± SE. *p < 0.05 and **p < 0.01.