Table 3.
Associations of baseline characteristics with the MRI markers among the participants of the Taizhou Imaging Study.
| MRI markers | Age (per year) | Gender (males vs females) | BMI (per kg/m2) | Education (per year) | Smoking (ever vs never smokers) | Alcohol drinking (ever vs never drinkers) | Hypertension (yes vs no) | Diabetes (yes vs no) | Hyperlipidemia (yes vs no) |
|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI)# | |||||||||
| Lacunes | 1.06 (0.98, 1.14) | 1.25 (0.46, 3.37) | 0.99 (0.93, 1.07) | 1.00 (0.94, 1.08) | 0.70 (0.27, 1.85) | 1.36 (0.70, 2.65) | 2.28 (1.43, 3.65) ** | 0.73 (0.38, 1.41) | 0.94 (0.60, 1.47) |
| WMH | 1.15 (1.02, 1.31) * | 0.76 (0.22, 2.55) | 0.96 (0.88, 1.06) | 1.01 (0.92, 1.12) | 0.45 (0.13, 1.53) | 1.14 (0.44, 3.02) | 5.45 (2.55,11.65) ** | 0.96 (0.41, 2.23) | 1.01 (0.53, 1.94) |
| CMB | 1.14 (1.03,1.26) * | 1.47 (0.49, 4.37) | 0.97 (0.89,1.05) | 1.02 (0.94, 1.10) | 0.64 (0.22, 1.92) | 1.21 (0.56, 2.63) | 2.98 (1.73, 5.13) ** | 0.55 (0.25, 1.22) | 1.12 (0.67, 1.22) |
| PVS | 1.03 (0.95, 1.12) | 0.60 (0.24, 1.52) | 0.97 (0.90, 1.04) | 1.00 (0.94, 1.08) | 0.42 (0.17, 1.06) | 1.15 (0.59, 2.25) | 2.66 (1.68, 4.22) ** | 0.71 (0.37,1.38) | 0.93 (0.59,1.45) |
| Number of SVD markers | |||||||||
| 1–2 vs 0 | 1.03 (0.95, 1.10) | 0.98 (0.45, 2.14) | 1.00 (0.93, 1.06) | 1.02 (0.96, 1.08) | 0.71 (0.33, 1.51) | 1.06 (0.60, 1.88) | 1.72 (1.15, 2.58) * | 0.62 (0.35, 1.10) | 0.91 (0.61, 1.34) |
| 3–4 vs 0 | 1.13 (1.00, 1,26) * | 1.18 (0.38, 3.65) | 0.97 (0.89, 1.06) | 0.99 (0.90, 1.08) | 0.88 (0.29, 2,68) | 0.93 (0.38, 2.27) | 4.46 (2.25, 8.84) ** | 0.75 (0.34, 1.66) | 0.82 (0.45, 1.49) |
| ICAS | 0.95 (0.85,1.07) | 1.00 (0.26,3.80) | 1.03 (0.94, 1.12) | 0.98 (0.90, 1.08) | 0.29 (0.07, 1.14) | 3.25(1.04,10.2) * | 4.13 (2.11, 8.11) ** | 0.58 (0.24, 1.42) | 1.51 (0.81, 2.83) |
| β (SE) # | |||||||||
| BGMF, % | −0.17 (0.07) * | 3.75 (0.74) ** | 0.15 (0.06) * | 0.01 (0.06) | −0.09 (0.72) | −0.63 (0.55) | −0.61 (0.39) | −0.41 (0.53) | 0.03 (0.38) |
| BPF, % | −0.02 (0.08) | 0.39 (0.81) | 0.05 (0.06) | 0.01 (0.06) | 0.31 (0.78) | −0.70 (0.60) | 0.35 (0.42) | 0.03 (0.58) | −0.22 (0.41) |
WMH, white matter hyperintensity; CMB, cerebral microbleeds; PVS, perivascular space; SVD, small vessel diseases; ICAS, intracranial arterial stenosis; BGMF, brain gray matter fraction; BPF, brain parenchymal fraction.
#Covariates listed in the table were mutually adjusted.
*P < 0.05.
**P < 0.01.