Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jan 24;9:663. doi: 10.1038/s41598-018-36855-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Tumor growth and angiogenesis is significantly reduced by exosome treatment. (A) Scheme of experimental design. Tumors were induced with four weeks of DMBA treatment and four injections of exosomes were administered every 3–4 days (B,C) Tumor growth in mm₃ tumor volume and relative tumor growth. indicates days of exosome treatment. Control tumors ar e shown as triangles and exosome treated tumors as circles. N = 9 (control), N = 8 (Exo). (D) Histological sections of tumors at day 25 (end-point) with Hematoxylin and eosin stain (H&E). Quantification of vessel density based on H&E sections is shown below. ▲ indicates vessels. (E) Dextran-Fitc (green), VE Cadherin (red) and Hoechst (blue) stained histological sections of tumors at day 25 (end-point). Upper panel: complete tumors, lower panel: zoom of selected tumor area. VE-Cadherin is only shown for zoom (lower panel). Graph shows quantification of vascular area based on dextran stain. Analysis: unpaired t-test. Bar graphs show average values, error bars: SEM.

Inline graphic — Tumor growth and angiogenesis is significantly reduced by exosome treatment. (A) Scheme of experimental design. Tumors were induced with four weeks of DMBA treatment and four injections of exosomes were administered every 3–4 days (B,C) Tumor growth in mm₃ tumor volume and relative tumor growth. indicates days of exosome treatment. Control tumors ar e shown as triangles and exosome treated tumors as circles. N = 9 (control), N = 8 (Exo). (D) Histological sections of tumors at day 25 (end-point) with Hematoxylin and eosin stain (H&E). Quantification of vessel density based on H&E sections is shown below. ▲ indicates vessels. (E) Dextran-Fitc (green), VE Cadherin (red) and Hoechst (blue) stained histological sections of tumors at day 25 (end-point). Upper panel: complete tumors, lower panel: zoom of selected tumor area. VE-Cadherin is only shown for zoom (lower panel). Graph shows quantification of vascular area based on dextran stain. Analysis: unpaired t-test. Bar graphs show average values, error bars: SEM.