Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jan 24;10:409. doi: 10.1038/s41467-018-08279-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — Associations of PAM phenotypes with neuropathology and cognitive decline. a −Log₁₀(p-values), weighted by direction of effect, indicating the strength of evidence for association of each brain-wide neuropathology measure with PAM. b –Log₁₀(p-values), weighted by direction of effect, indicating the strength of evidence for association of each measure of longitudinal cognitive decline with PAM. The red dotted lines in panel a indicate corrected statistical significance thresholds, and the blue dotted lines in both panels indicate uncorrected thresholds of p = 0.05. All p-values are two-sided and calculated from parameter estimates of iterative re-weighted least-squares regression. Model covariates included age at death, postmortem interval, APOE ε4 status, and top three EIGENSTRAT principal components (n_MF = 225, n_IT = 219, n_PPUT = 198, n_VM = 218)