Table 2.
Association between levels of myocardial fibrosis and those of cardiac lipid species, plasma miRNAs, adiposity and leptin in rats submitted to myocardial infarction fed a standard diet (AMI) or a high fat diet (HFD-AMI) and rats fed a control diet and with SHAM operation (CT).
| Variable | Beta coefficient | 95% confidence interval | p |
|---|---|---|---|
| Total TG | 0.156 | 0.06–0.25 | 0.003 |
| Mitochondrial TGs | 0.99 | 0.55–1.44 | <0.001 |
| Adiposity | 0.18 | 0.03–0.32 | 0.017 |
| Leptin | 0.00 | 0.00–0.00 | 0.011 |
| Total CL | −0.19 | −0.33–0.05 | 0.010 |
| CL (22:6) | 1.71 | 0.18–3.23 | 0.030 |
| CL (20:4) | 0.49 | 0.11–0.87 | 0.015 |
| CL (18:2)4 | −0.31 | −0.48–0.14 | 0.001 |
| CER (22:0) | −15.79 | −25.78–5.79 | 0.004 |
| miRNA 194-5p | −2.30 | −4.38–0.22 | 0.032 |
| miRNA 301a-3p | −1.89 | −3.42–0.36 | 0.032 |
| miRNA 144-5p | −1.62 | −2.82–0.41 | 0.012 |
| miRNA 15b-5p | −2.05 | −3.19–0.92 | 0.001 |
CER: ceramide; TGs. Triglycerides; CL: cardiolipins.