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. 2019 Jan 24;9:734. doi: 10.1038/s41598-018-37042-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Key phylotypes of the gut microbiota responding to age identified using LEfSe. The left histogram shows the LDA scores computed for features (OTU level) differentially abundant among different phases. The right heat map shows the mean relative abundance (log-transformed) of OTUs in each group. The values on the color bar represent the mean sequence number with log-transformed. Phylotype names marked with different colors indicate the corresponding phylum (blue: Proteobacteria, green: Firmicutes; orange: Bacteroidetes red: Verrucomicrobia; purple: Actinobacteria). Sample sizes are the same as Fig. 1.