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. 2019 Jan 24;9:658. doi: 10.1038/s41598-018-37074-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cenerimod suppressed the infiltration of immune cells into the skin on Scl-cGVHD mice. (A) Shown are representative immunohistochemical staining of the skin. Skin tissues were harvested 42 days after BMT. The number of CD4⁺ T cells, CD8⁺ T cells, CD11b⁺ cells and cells containing phosphorylated Smad3 (pSer425) per high-power field (HPF) in immunohistochemical-stained slides from groups of syngeneic mice, vehicle-treated mice, cenerimod-treated mice from day 0 to day 42, and from day 22 to day 42 after BMT (n = 4–5 mice per group; **p < 0.01). Scale bar for CD4⁺ T cells, CD8⁺ T cells, CD11b⁺ cells, 50 μm. Scale bar for p-Smad3 cells, 20 μm. (B) Representative results demonstrate the frequency of skin-infiltrating CD11b⁺ cells, CD4⁺ T cells, and CD8⁺ T cells within indicated gates among total skin live cells. Number of skin CD11b⁺ cells, CD4⁺ T cells and CD8⁺ T cells 14 days after BMT are also shown. Values are the mean ± SEM of 4–5 mice per group (*p < 0.05, ***p < 0.001). All data are representative of two independent experiments.