Table 4.
CA6 SNP and haploblock associations with being caries-affected or caries-free.
| SNP | Haploblock | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| SNP number | Name | Allele | Caries-affected vs. Caries-free | Haplo-block number | Allele | Frequency | Caries-affected vs. Caries-free | ||
| OR (95%CI) | pchi2 | OR (95%CI) | pchi2 | ||||||
| 1 | rs6688840 | T/C | 1.1 (0.5, 2.3) | 0.895 | Block 1 | CT | 0.717 | 0.9 (0.5, 1.6) | 0.748 |
| 2 | rs2781087 | G/T | 1.1 (0.6, 1.9) | 0.749 | CG | 0.167 | 1.1 (0.6, 2.2) | 0.784 | |
| 3 | rs1475734 | G/T | 1.0 (0.5, 2.1) | 0.955 | TG | 0.116 | 1.1 (0.5, 2.3) | 0.894 | |
| 4 | rs6692694 | C/T | 1.1 (0.6, 2.1) | 0.783 | |||||
| 5 | rs17032875 | C/T | 1.1 (0.6, 1.8) | 0.744 | |||||
| 6 | rs12067941 | C/A | 1.2 (0.5, 2.6) | 0.663 | |||||
| 7 | rs12568902 | A/T | 1.0 (0.4, 2.5) | 0.955 | |||||
| 8 | rs6577541 | G/C | 1.1 (0.6, 1.8) | 0.821 | Block 2 | CCAC | 0.348 | 1.0 (0.6, 1.7) | 0.948 |
| 9 | rs2274327 | C/T | 1.2 (0.7, 2.0) | 0.514 | GTCC | 0.329 | 0.8 (0.5, 1.4) | 0.449 | |
| 10 | rs2274328 | C/A | 1.0 (0.5, 1.7) | 0.982 | GCAT | 0.220 | 0.9 (0.5, 1.7) | 0.828 | |
| 11 | rs17032907 | C/T | 1.1 (0.6, 1.9) | 0.815 | GCAC | 0.043 | 1.7 (0.5, 6.8) | 0.479 | |
| 12 | rs11121278 | G/C | 1.4 (0.6, 3.5) | 0.468 | GCCC | 0.036 | 5.4 (0.7, 43.5) | 0.065 | |
| 13 | rs12021597 | A/G | 1.9 (1.1, 3.4) | 0.023 | GCCT | 0.011 | 1.3 (0.1, 14.4) | 0.854 | |
| 14 | rs17032912 | G/C | 1.5 (0.8, 3.0) | 0.214 | |||||
| 15 | rs7545200 | G/A | 1.0 (0.6, 1.8) | 0.930 | Block 3 | GTA | 0.401 | 0.6 (0.4, 1.1) | 0.063 |
| 16 | rs1832262 | C/T | 1.7 (1.0, 2.8) | 0.057 | GCA | 0.296 | 1.9 (1.1, 3.3) | 0.037 | |
| 17 | rs6691526 | A/G | 1.2 (0.6, 2.1) | 0.637 | ACG | 0.240 | 0.9 (0.5, 1.6) | 0.636 | |
| 18 | rs3765965 | T/C | 1.2 (0.6, 2.3) | 0.538 | ACA | 0.062 | 1.4 (0.5, 4.3) | 0.508 | |
| 19 | rs2274334 | G/T | 1.1 (0.4, 3.6) | 0.850 | |||||
| 20 | rs10864376 | T/C | 2.1 (1.2, 3.7) | 0.009 | Block 4 | CCC | 0.461 | 0.6 (0.3, 0.9) | 0.028 |
| 21 | rs3737665 | T/C | 2.3 (1.2, 4.4) | 0.014 | CCG | 0.217 | 0.9 (0.5, 1.7) | 0.776 | |
| 22 | rs12138897 | G/C | 1.8 (1.1, 2.9) | 0.028 | TTG | 0.217 | 2.3 (1.2, 4.4) | 0.014 | |
| 23 | rs3765964 | A/G | 1.5 (0.9, 2.4) | 0.160 | TCG | 0.105 | 1.3 (0.6, 3.1) | 0.518 | |
| 24 | rs6577546 | A/G | 0.9 (0.5, 1.7) | 0.851 | Block 5 | AG | 0.475 | 0.8 (0.5, 1.3) | 0.314 |
| 25 | rs6680186 | A/G | 1.4 (0.8, 2.2) | 0.242 | AA | 0.301 | 1.3 (0.8, 2.4) | 0.319 | |
| 26 | rs7533137 | G/A | 1.1 (0.6, 2.1) | 0.697 | GA | 0.219 | 1.1 (0.6, 2.0) | 0.754 | |
| 27 | rs7513804 | T/C | 1.2 (0.7, 1.9) | 0.573 | |||||
Alleles in bold indicate significant positive associations and in italic negative associations at FDR of < 0.25 (bold underline for significant differences at FDR ≤ 0.06).