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. 2019 Jan 24;9:522. doi: 10.1038/s41598-018-36682-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Immunolocalization of type I collagen in fibroblasts treated for 48 h with (A) control (cell culture medium), (B) 100 μM AA solution, (C,D) DRV5 containing 100 μM AA. Thin arrows evidence positive intracellular labeling for type I collagen. Thick arrows evidence intense labeling of collagen I in the extracellular matrix. Red arrows show multiple dividing cells in the groups treated with (B) AA solution and (C,D) DRV5. Collagen was labeled with Alexa Fluor® 488 and nucleus with DAPI. Cells were analyzed by fluorescence microscopy with a 20x objective. Scale bars = 50 μm.