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. 2019 Jan 24;9:545. doi: 10.1038/s41598-018-36921-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) The top 10 canonical pathways associated with IC mRNA expression are presented. (B) IC specific inhibition of Rxrα mTNA expression. IC reporter mice were infected with UPEC or saline and Tdt⁺ (IC) and Tdt⁻ (Non-IC) cells were enriched. Rxrα mRNA was measured normalized to GAPDH. IC cells showed significant inhibition of mRNA expression upon UPEC exposure (3.64 ± 0.44 in saline vs. 1.97 ± 0.85 in UPEC, P = 0.008) compared to NIC (9.63 ± 1.26 in saline vs. 9.34 ± 1.67 in UPEC, P = 0.85) cells. N = 4 experiments, each using a separate sort consisting of kidneys from 1–2 mice. (C) The top 10 canonical pathways associated with PC mRNA expression are presented.