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. 2019 Jan 24;9:597. doi: 10.1038/s41598-018-37160-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Myo10 is not important for Fcγ receptor-mediated phagocytosis. (A) Model system for Fcγ receptor-mediated phagocytosis. Time-lapse images (XZ and reconstructed 3D views), obtained by spinning disk confocal microscopy, of a Myo10 knockout (Myo10^tm2/tm2) macrophage engulfing freshly isolated hRBCs (human red blood cells) opsonized with mouse immunoglobulin G (mIgG). At t = 0 s, a mIgG-hRBC has already been ingested (labeled 1). At t = 60 s, a nascent phagocytic cup, extending from the first cup, is forming around a second hRBC (labeled 2). A third cup, emerging from the cell body, can be seen at t = 240 s. (B) Kinetics of phagocytic cup formation. XY, XZ and YZ views of the confocal data sets (n = 19–38 events per group; 2 independent experiments) were used to measure the kinetics of single phagocytic cup formations.