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. 2019 Jan 24;9:597. doi: 10.1038/s41598-018-37160-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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High penetrance of simple syndactyly in Myo10^tm2/tm2 mice. (A) Examples of normal paws in WT mice (top panel) and syndactyly in Myo10^tm2/tm2 mice (lower panel). Typically, digits 2 and 3 or digits 3 and 4 were fused. The frequency (n = 25 mice) and variations (assessed in n = 24 mice) of the phenotype (simple syndactyly) are shown in the pie charts. As indicated below the pie charts, the unusual combination of pigmentation defects and syndactyly has been sporadically reported in cases of Waardenburg syndrome, type 3, which usually includes loss of hearing (not tested). (B) Three dimensional (3D) micro-computed tomography (µCT) images of mouse paws. The µCT images were obtained from the same paws shown above (Roman numerals indicate the matching images). (C) X-gal staining of whole-mount Myo10^+/tm2 embryos showing Myo10 expression in the developing limb bud (E10.5) and digit primordia (E12.5 and E13.5). The inset at E10.5 shows an X-gal stained (control) WT embryo. (D) Histological section of an X-gal stained autopod (and distal zeugopod) at E14.5. The section was counterstained with eosin (pink).