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. 2019 Jan 24;9:752. doi: 10.1038/s41598-018-37334-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of mammary tumors and tumor resection on mRNA expression of inflammatory markers in brain regions that regulate sickness behavior. Mean ± SEM TaqMan quantitative gene expression of Il-1β (A–C), Il-6 (D–F), Tnf-α (G–I) and Cd11b (J–L) in the hippocampus, hypothalamus and frontal cortex in surgical controls, tumor-bearing mice, and tumor-resected mice (n = 10–20/group); *p < 0.05 relative to LPS-treated tumor-free mice at the same time point; ^#p < 0.05 relative to tumor-bearing mice at the same time point; ^&p < 0.05 relative to PBS-treated mice; ⁺p < 0.05 relative to 24 h.