Table 1.

Histological scores for intestinal mucositis.

Intestinal segments	Experimental groups
	Control	5-FU	5-FU + P0.8	5-FU + P4	P4
Duodenum	0 (0–0)	2 (2–2)#	0 (0–1)#*	0 (0–1)*	0 (0–0)*
Jejunum	0 (0–0)	3 (3–3)#	2 (0–2)#	1 (0–2)*	1 (0–1)*
Ileum	0 (0–0)	2.5 (2–3)#	1 (1–2)	1.5 (1–2)	0 (0–1)*
Colon	0 (0–0)	3 (3–3)#	2 (0–2)	1 (1–2)	0 (0–1)*

Data represent median values (and range) of scores from 0 to 3: Score 0, normal histological findings; Score 1, villus blunting, loss of crypt architecture, sparse inflammatory cell infiltration, vacuolization and edema normal muscle layer; Score 2, villus blunting with fattened and vacuolated cells, crypt necrosis, intense inflammatory cell infiltration, vacuolization and edema and normal muscle layer; Score 3, villus blunting with fattened and vacuolated cells, crypt necrosis, intense inflammatory cell infiltration, vacuolization and edema and muscle layer showing edema, vacuolization and neutrophilic infiltration. Villus alterations were not considered for colon scores. Data were analyzed with Kruskal-Wallis and Dunn’s tests (n = 8). ^#P < 0.01 versus control group, *P < 0.01 versus 5-FU group.