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. 2019 Jan 24;9:523. doi: 10.1038/s41598-018-36636-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histograms showing the normalized distribution probability of pathways identified by transcriptomics alone, proteomics alone, and the combination of transcriptomics and proteomics. The bars show the proportion of each group among the total number of pathway types identified by Reactome (blue), PWO (orange), or KEGG (green). The top panel shows the distribution of the 115 common pathways identified by both transcriptomics and proteomics GSEAs (T&P). The middle panel shows the distribution of the 304 pathways identified only by the transcriptomics GSEA (T). The bottom panel shows the distribution of the 140 pathways identified only by the proteomics GSEA (P). The sum of all the groups in each section is 1.0 for all three panels.