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. 2019 Jan 24;9:523. doi: 10.1038/s41598-018-36636-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Chord diagram of the likely relationships among drug candidates, proteins, and pathways identified by the multiple omics analyses. Based on the drug repositioning method, eight drugs, five proteins, and 33 pathways were selected as potential candidates for use in the development of treatments for DHF. The drug candidates, proteins, and pathways are shown in green, orange, and cyan, respectively. Connections show the interactions among the drug candidates, proteins, and pathways. The Reactome, PWO, and KEGG pathways are shown in blue, orange, and green, respectively.