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. 2019 Jan 24;9:615. doi: 10.1038/s41598-018-36349-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Network analysis of the six ginsenoside biosynthesis candidate PgCYP genes and all 10 published ginsenoside biosynthesis genes. The network was constructed based on their expressions in the four-year-old roots of 42 cultivars. (A) The co-expression network constructed from the six PgCYP genes identified in this study indicated by balls, 16 transcripts of the 10 published ginsenoside biosynthesis genes indicated by diamonds, and 9 mono- and total ginsenosides indicated by cubes. The network was constructed at P ≤ 5.0E-02. (B) The clusters constituting the network. Different clusters are indicated by different colors. (C) Tendency that these ginsenoside biosynthesis related genes form a network, with the randomly-selected ginseng unknown genes as controls: variation in number of nodes. (D) Tendency that these ginsenoside biosynthesis related genes form a network, with the randomly-selected ginseng unknown genes as controls: variation in number of edges. (E) Statistics of variation in number of nodes in the network. (F) Statistics of variation in number of edges in the network. Different capital letters, significant at P ≤ 0.01. Error bar, standard deviation for 20 replications.