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. 2019 Jan 24;9:651. doi: 10.1038/s41598-018-36912-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Neuronal activity-induced IEG and basal transcriptional expression. WT1, A-T1 and ATM-KO neurons at DIV55 were incubated overnight with TTX and then untreated or treated with KCl for 1 hr, harvested and analysed by RNA-seq. (a) Heat map of the stimulus-induced IEGs. (b) heat map of genes differentially expressed in unperturbed WT1 compared to A-T1 and ATM-KO1 neurons. These genes are involved in CNS development, maintenance, and synaptic plasticity. Data are of two independent replicates.