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. 2018 Sep 27;176(4):554–570. doi: 10.1111/bph.14464

Figure 4.

Figure 4

Sulfur flow from cysteine via H2S to sulfate and thiosulfate. Cysteine catabolism via H2S proceeds via three distinct pathways that involve either CBS (1M54), CSE (2NMP), or GOT1/2 (3II0/5AX8) and MPST (4JGT). Within the mitochondrial matrix, H2S is oxidized via SQR (3H8L) to GSH persulfide, which is further converted to either sulfite by PDO (4CHL) or thiosulfate by TST (1RHD). The shapes of the enzymes involved are depicted according to the crystal structures available.