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. 2019 Jan 24;9:594. doi: 10.1038/s41598-018-37444-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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APP/Bmi1^+/− mice show genetic cooperation in disease onset and severity. (a) Kaplan-Meyer representation of the survival curves of WT (n = 11), Bmi1^+/− (n = 13), APP (n = 6) and APP/Bmi1^+/− (n = 6) mice. (b) IHC staining for p-Tau (PHF1) on cortical sections of 6 month-old WT (n = 3), Bmi1^+/− (n = 3), APP (n = 3),and APP/Bmi1^+/− (n = 3) mice. Scale bar: 20μm. Scale bar in the inset: 8μm. (c) Quantification of p-Tau-positive neurons shown in (b). (d) IHC for amyloid (DE2B4) on cortical sections of 6-month old WT (n = 3), Bmi1^+/− (n = 3), APP (n = 3), and APP/Bmi1^+/− (n = 3) mice. Scale bar: 20μm. (e) Quantification of amyloid-positive cells shown in (d). Values are mean ± SEM. *P < 0.05; (**) < 0.01; (***) < 0.001; Student’s t-test.