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R. rickettsii-specific IgG response following vaccination and infection challenge. Antigen-specific IgG was measured in the plasma at multiple time points by an ELISA. Average absorbance values for dogs within each group were plotted against the blood sampling days. Antigens used for the ELISA included recombinant antigens (Adr2 and OmpB-4) (A) and R. rickettsii whole-cell lysate-derived antigens (B).
