Table 1.

Characteristics of articles in the meta-analysis.

References	Case	Operation type	Testing index	Acquisition time	Threshold	Measurement	Follow-up time	MAC	NOS
Ausset et al., 2008	87	Hip surgery	cTnI	The first three postoperative days	>0.08ng/ml	Ortho Vitros ECi; Ortho-Clinical Diagnostics	during hospital and 1 year	cardiac death, MI,HF, ACS	7
Biccard et al., 2012	788	Vascular surgery	cTnI	Immediately,1,2,3,7 days postoperation	–	Advia Centaur Xp (Siemens Healthcare)	30 d	Death or cTnI equal to or higher then reference level	7
Cagini et al., 2014	294	Pneumonectomies, lobectomies, anatomical segmentectomies or wedge resections	BNP	Before and 1,4 days postoperation	>118.5pg/ml	–	24h	AF,PSVT,VT, AMI,UP, ARF, TIA,DVT, thromboembolic events	6
Chong et al., 2009	102	Emergency orthopedic surgery	cTnI	Pre-operation and on days 1, 2, and 3 post-operation	>0.3 mcg/l	Architect STAT Troponin I assay (Abbott Diagnostics)	In hospital / 1 year	MI, HF, AF, major arrhythmia	7
Dawson-Bowling et al., 2008	108	Fractured of neck and femur	cTnT	Admission day 1–2 postoperation	>0.03ng/ml	–	In hospital	MI, HF, unstable angina, major arrhythmias requiring treatment	5
Feringa et al., 2007	335	Abdominal aortic repair, lower extremity revascularization	NT-proBNP	Before surgery	≥319 ng/L	Electrochemiluminescence immunoassay	14 ± 6 year	Cardiac death, MI	8
Gibson et al., 2006	44	Below knee amputation	cTnT	Before surgery	>0.3ng/ml	Elecsys 2010 (Roche Diagnostics)	6 weeks postoperation	Non-fatal MI, cardiac death	9
Gillmann et al., 2014	455	Elective open aortic, peripheral vascular, or carotid surgery	cTnT	Before and 24 h postoperation	≥17.8ng/L	Immunoassay	30 days	Cardiovascular death, MI, ischemia	7
Golubović et al., 2018	79	Abdominal, thoracic, orthopedic, and vascular surgery	cTnT	48h prior to surgery	>7.5ng/L	Immunoluminometric electrochemiluminescence immunoassay	14 days	HF, MI, all-cause mortality	6
Kim et al., 2016	506	Non-cardiac surgery of elderly patients with normal left ventricular systolic function	NT-proBNP	Before surgery	≥425.3pg/ml	Elecsys 2010 (Roche Diagnostics)	30 d	Cardiac death, AMI, HF, stroke, AF	7
Kim et al., 2018	262	Hip fracture surgery	cTnI	Before surgery	>6.5ng/L	Immunoassay analyzer	90 days	All-cause deaths, HF, AF, MI	7
Kopec et al., 2017	572	Major noncardiac surgery,	cTnT NT-proBNP	Before surgery	≥14 ng/L/ >108ng/L	Elecsys 2010 (Roche Diagnostics)	The first 3 days after surgery	MI	7
Long et al., 2016	1120	Primary total knee arthroplasty	BNP	Before surgery	≥822.5pg/ml	Elecsys electrochemiluminescence immunoassay (ECLIA)	≥2 years	AF, AHF, MI	6
Lopez-Jimenez et al., 1997	772	Noncardiac surgery without clinical evidence of severe ischemia	cTnT	In the recovery room and during the next 2 days	>0.1ng/ml	–	6 months	Cardiac deaths, nonfatal MI, unstable angina	8
Martins et al., 2011	101	Aortic and peripheral artery revascularizations	Hs-CRP	before surgery	>100 mg/L	VITROS Chemistry Products (Ortho-Clinical Diagnostics)	Until discharge	AMI, noncardiac death, AF, HF, ARF	8
Oscarsson et al., 2009b	186	Emergent or urgent non-cardiac surgery	cTnT NT-proBNP	Within 1 h before surgery	0.06 μg/l/>1800 pg/ml	Stratus CS Acute CareTM Diagnostic System (Dade International Holding GmBH)	30 d	AMI, cardiovascular death	8
Oscarsson et al., 2009a	69	Unscheduled hip surgery	NT-proBNP	1 h before surgery	≥3984ng/ml	Stratus CS Acute CareTM Diagnostic System (Dade International Holding GmBH)	30 days after operation	AMI, cardiac events	8
Oscarsson et al., 2004	161	Gynecology, orthopedics, urology, vascular surgery	cTnT	5−7 h postoperation	≥0.02 ng/ml	ECLIA on Elecays 2010 analyzer	1 year	AMI, coronary intervention	8
Owens et al., 2007	91	Autogenous lower extremity revascularization	Hs-CRP	Immediately before surgery	>5 mg/L	BD Diagnostics	342 days (range, 36 to 694)	Stroke, MI, cardiac revascularization procedure, death fromAny cause	8
Rajagopalan et al., 2008	136	Subcritical limb ischemia or abdominal aortic aneurysm (AAA) repair	NT-proBNP	Before surgery	>308pg/ml	Elecsys 2010 (Roche Diagnostics)	2 days	Revascularization procedure, or death from any cause	6
Rajagopalan et al., 2011	136	Open abdominal aortic aneurysm (AAA) repair and aorto-femoral and infrainguinal revascularization for critical limb ischaemia	NT-proBNP	The day before surgery and on the first postoperative day after surgery	≥359pg/ml	Electrochemiluminescence sandwich immunoassay (ECLIA)	2 years	Death due to an obvious cardiac cause or coronary revascularization	7
Scrutinio et al., 2011	239	Elective carotid or peripheral lower extremity revascularization or aortic surgery	Hs-CRP	On the preoperative day	>3.2 mg/L	Siemens Healthcare Diagnostics	30days	cTn-I elevation above the decision limit of 0.15 g/L, death, ACS, stroke, AHF	8
Shroff et al., 2012	376	Kidney transplantation	cTnI	Before surgery	≥0.04 ng/ml	Vitros, Ortho Clinical Diagnostics	In hospital	Death, MI, arrhythmia or HF	8
Stone et al., 2014	118	Lower extremity, EVT	hs-CRP/ BNP	Before surgery	>0.8mg/dl/ >100pg/ml	Immunometric assay	1year, 2 years	Stroke, MI, death	6
Vetrugno et al., 2012	227	Elective prosthesis orthopedic surgery	BNP	Before surgery	>39 pg/dl	Bayer ADVIA Centaur™	In hospital	AF, AHF, non-fatal/fatal MI	7
Winkel et al., 2010	513	Vascular surgery	cTnT	Before surgery	>0.1ng/ml	Electrochemiluminescence immunoassay (TropT version 2, Roche Diagnostics GmbH).	Postoperative days 1,3, 7, 30 2 years	Cardiac death, MI	8

NOS, Newcastle-Ottawa Scale; cTnI, cardiac troponin I; BNP, brain natriuretic peptide; NT-proBNP, amino-terminal pro-hormone of brain natriuretic peptide; HF, heart failure; AHF, acute heart failure; ACS, acute coronary syndrome; AF, atrial fibrillation; PSVT, paroxysmal supraventricular tachycardia; VT, ventricular tachycardia; UP, angina pectoris; MI, myocardial infarction; AMI, acute myocardial infarction; DVT, deep vein thrombosis; ARF, acute renal failure; TIA, transient ischemic attack.