Table 2.

Summary of Bootstrap Analysis Predicting Follow up Cognition from Polygenic Score for AD

	Total Effect of PGS on Cognition a	MV	Effect of PGS on MV	Effect of MV on Cognition	Direct Effect of PGS on Cognition b	Indirect Effect of PGS on Cognition c
Trait-Level Analysisd
	−.0.09*				−0.07*
		Neuroticism	0.02**	−0.25***		−0.005(−.010;−.001)
		Extraversion	0.000	−0.29**		−0.00(−.004;.004)
		Openness	−0.01	0.34***		−0.003(−.008;.001)
		Agreeableness	0.000	−0.39***		−0.00(−.005;.004)
		Conscientiousness	−0.01*	0.34***		−0.004(−.009;−.0002)
Facet-Level Analysise
	−.10**				−.10*
		Self-control	−0.009	0.10*		−0.001(−.004;.001)
		Order	−0.01	0.06		−0.001(−.004;.0007)
		Industriousness	−0.03*	0.08		−0.003(−.007;.0002)
		Traditionalism	0.01	−0.07		−0.00(−.003;.001)
		Virtue	−0.006	0.03		−0.00(−.002;.001)
		Responsibility	−0.007	0.10		−0.00(−.003;.001)

Note.

^*p<.05

^**p<.01

^***p< .001

PGS AD: Polygenic Score for Alzheimer Disease ; MV: mediating variable.

Coefficients are unstandardized coefficients

^aRelationship between PGS AD and follow-up cognition, controlling for age, sex, baseline cognition and ancestry-specific principal components

^bRelationship between PGS AD and follow-up cognition, with mediators included in the model and controlling for age, sex, baseline cognition and ancestry-specific principal components

^cBootstrap estimates and 95% bias-corrected confidence interval for indirect effects of PGS on follow-up cognition through mediators, controlling for age, sex, baseline cognition and ancestry-specific principal components

^dAnalysis conducted with the five personality traits as mediators (N= 6429)

^eAnalysis conducted with the six conscientiousness facets as mediators (N=6239)