Fig. 3.

RET inhibition has no effect on colonic compliance in a model of acute visceral hypersensitivity. In comparison with rats sensitized with acetic acid and dosed orally with vehicle (n = 5), rats dosed with 10 mg/kg GSK3179106 (n = 5) demonstrated no difference in the mean colon volumes at 0, 20, 40, and 60 mm Hg distension pressure determined from barostat measurements. Two-way RM-ANOVA and Bonferonni’s post-hoc test for multiple comparisons revealed no statistical difference between vehicle and GSK3179106 treatment.