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. 2018 Dec 26;5(1):122–144. doi: 10.1021/acscentsci.8b00746

Figure 8.

Figure 8

In vivo anticancer activities of free Dox and different Dox nanoformulations for chemo-immunotherapy and concurrent CIRT in the Daudi xenograft tumor model. (A) Treatment schedule and tumor growth curve of individual mice in the control and treatment groups. The treatments were three 3.5 mg/kg doses of free/encapsulated Dox and three 5 μg/kg doses of free/conjugated SHAL. The mice in the concurrent CIRT group received three 5 Gy XRT treatments 24 h after the i.v. administration of the therapeutics. (B) Kaplan–Meier survival curves for mice in the nontreatment group and in (i) the chemo-immunotherapy groups and (ii) the concurrent CIRT groups (n = 7 or 8 per group; * denotes p < 0.05, i.e., statistically significant).