Table 2.
Neuroimaging features of the study population stratified by progression
| Variable | Patients without progression | Patients with progression | p Value |
|---|---|---|---|
| N = 103 | N = 57 | ||
| Presence of lacunar infarcts | 47 (45.6) | 34 (59.6) | 0.219 |
| Scores of WMHs (Fazekas scale) | |||
| Periventricular score | 1.53 ± 0.72 | 2.13 ± 0.71 | <0.001 |
| Deep white matter score | 1.43 ± 0.68 | 2.03 ± 0.74 | <0.001 |
| Total score | 2.96 ± 1.35 | 4.16 ± 1.39 | <0.001 |
| Extensive WMHsa | 36 (34.9) | 37 (64.9) | <0.001 |
| Presence of CMBs (≥1) | 24 (23.3) | 26 (45.6) | 0.027 |
| Moderate‐ and high‐grade BG‐EPVS (10–25 or >25) | 13 (12.6) | 22 (38.6) | 0.012 |
| Total cSVD Score n (%) | |||
| 0 point | 25 (24.3) | 2 (3.5) | <0.001 |
| 1 point | 37 (35.9) | 3 (5.3) | |
| 2 point | 20 (19.4) | 15 (26.3) | |
| 3 point | 17 (16.5) | 17 (29.8) | |
| 4 point | 4 (3.9) | 20 (35.1) | |
Bold values are significant with p < 0.05.
BG‐EPVS: basal ganglia enlarged perivascular spaces; CMBs: cerebral microbleeds; WMH: white matter hyperintensities.
a
Extensive WMHs: periventricular WMH (Fazekas 3) or deep WMH (Fazekas 2 + 3).